The N‐end rule denotes the relationship between the identity of the amino‐terminal residue of a protein and its in vivo half‐life. Since its discovery in 1986, the N‐end rule has generally been described by a defined set of rules for determining whether an amino‐terminal residue is stabilizing or not. However, recent studies are revealing that this N‐end rule (or N‐degron concept) is less straightforward than previously appreciated. For instance, it is unveiled that N‐terminal acetylation of N‐terminal residues may create a (...) degradation signal (Ac‐degron) that promotes the degradation of target proteins. A recent high‐throughput dissection of degrons in yeast proteins amino termini intriguingly suggested that the hydrophobicity of amino‐terminal residues—but not the N‐terminal acetylation status—may be the indispensable feature of amino‐terminal degrons. Herein, these recent advances in N‐terminal acetylation and the complexity of N‐terminal degradation signals in the context of the N‐degron pathway are analyzed. (shrink)

Using everyday language, spatial concepts, visualizations and his renowned "Feynman diagrams," the author clearly and humorously communicates the substance and spirit of QED (quantum electodynamics).

An integrative explanation proposes that culture and gender interact to produce fundamentally different patterns of association between positive and negative emotions. People in independent-based cultures (e.g. the United States) experience emotions in oppositional (i.e. bipolar) ways, whereas people in interdependent-based cultures (e.g. China) experience emotions in dialectic ways. These patterns are stronger for women than men in both cultures. In support of the theory, Study 1 showed that positive and negative emotions are strongly correlated inversely for American women and weakly (...) correlated inversely for American men, but strongly correlated positively for Chinese women and weakly correlated positively for Chinese men. In Study 2, findings for Koreans, although mixed, were closer to the results for Chinese. (shrink)

Topics in Cognitive Science, Volume 13, Issue 1, Page 63-78, January 2021.

Sex chromosomes can differ between species as a result of evolutionary turnover, a process that can be driven by evolution of the sex determination pathway. Canonical models of sex chromosome turnover hypothesize that a new master sex determining gene causes an autosome to become a sex chromosome or an XY chromosome pair to switch to a ZW pair (or vice versa). Here, a novel paradigm for the evolution of sex determination and sex chromosomes is presented, in which there is an (...) evolutionary transition in the master sex determiner, but the X chromosome remains unchanged. There are three documented examples of the novel paradigm, and it is hypothesized that a similar process could happen in a ZW sex chromosome system. Three other taxa are also identified where the novel paradigm may have occurred, and how it could be distinguished from canonical trajectories in these and additional taxa is also described. (shrink)

Ethical problems with stakeholder relationships sometimes occur because organizational members are operating out of narrowly scripted organizational routines that do not include an explicit ethical component. In this article we describe methods of single-loop, double-loop, and triple-loop action learning that aim at helping organizational members develop understandings that incorporate conscious ethical considerations in stakeholder relationships. We describe the extent to which these methods achieve "second-order" change in the direction of ethical stakeholder relationships, give examples of the use of each of (...) the methods, and we consider their strengths and limitations for achieving the desired change. (shrink)

Signed languages display a variety of pointing signs that serve the functions of deictic and anaphoric pronouns, possessive and reflexive pronouns, demonstratives, locatives, determiners, body part labels, and verb agreement. We consider criteria for determining the linguistic status of pointing signs. Among those criteria are conventionality, indexicality, phonological compositionality, being subject to grammatical constraints, and marking the kinds of grammatical distinctions expected of pronouns. We conclude that first-person points meet all these proposed criteria, but that nonfirst person points are in (...) part gestural. Lastly, we review evidence for the grammaticization over time of systems of pointing signs within signed languages. (shrink)

What can and should we do as managers and administrators when our sense of personal morality is at odds with our organization's behavior? Among the many alternatives are: (1) not think about it; (2) go along and get along; (3) protest; (4) conscientiously object; (5) leave; (6) secretly blow the whistle; (7) publicly blow the whistle; (8) secretly threaten to blow the whistle; (9) sabotage; and, (10) negotiate and build consensus for a change in the unethical behavior. This article considers (...) the advantages and disadvantages of these ten types of strategies based on some philosophy, game theory and everyday pragmatics. (shrink)

Núñez et al. (2019) argue that cognitive science has failed either “to transition to a mature inter‐disciplinary coherent field” (p. 782) or “to generate a successful [Lakatosian] research program” (p. 789). We argue that the former was never the intention of many early researchers within the field, while the latter is an inappropriate criterion by which to judge an entire discipline. However, we concur with Núñez et al. (2019) that the individual disciplinary balance within cognitive science has changed over time. (...) Of particular concern is the fact that the use of computational methods appears to be on the wane. (shrink)

Blokpoel reminds us of the importance of consistency of function across Marr's levels, but we argue that the approach to ensuring consistency that he advocates—a strict relation through exact implementation of the higher level function at the lower level—is unnecessarily restrictive. We show that it forces overcomplication of the computational level (by requiring it to incorporate concerns from lower levels) and results in the sacrifice of the distinct responsibilities associated with each level. We propose an alternative, no less rigorous, potential (...) characterization of the relation between levels. (shrink)

This volume of essays is an important introduction to the thought of one of the twentieth century's most significant yet underappreciated philosophers, Richard McKeon. The originator of philosophical pluralism, McKeon made extraordinary contributions to philosophy, to international relations, and to theory-formation in the communication arts, aesthetics, the organization of knowledge, and the practical sciences. This collection, which includes a philosophical autobiography as well as the out-of-print title essay "Freedom and History" and a previously unpublished essay on "Philosophic Semantics and (...) Philosophic Inquiry," is a testimony to the range and systematic power of McKeon's thinking for the social sciences and the humanities. (shrink)

Can ethical character be stimulated and enabled? Cognitive understanding of organizational ethics issues is important and necessary, but not sufficient. Ethical behavior does not emerge automatically. Effective political method is necessary. While it may be difficult to teach ethical character, nonetheless, skill development with respect to joined ethics understanding and action-learning methods can help us develop the skills and confidence we need to actualize our ethical characters and social concerns. An action-learning approach to organizational ethics can help stimulate and enable (...) ethical character. (shrink)

Leader-managers face a myriad of competing values when they engage in ethical decision-making. Few studies help us understand why certain reasons for action are justified, taking precedence over others when people choose to respond to an ethical dilemma. To help address this matter we began with a qualitative approach to disclose leader-managers' moral motives when they decide to address a work-related ethical dilemma. One hundred and nine military officers were asked to provide their reasons for taking action, justifications of their (...) reasons, and to explain these justifications. We used network analysis techniques to identify a hierarchical motive structure. The motive structure is a cognitive map that identifies ethical motives and perceptions of how these ethical motives relate to each other. The motives identified represent classic conceptualizations of moral behavior; namely, virtue theories, consequentialism, and deontological theories, along with another category that expressed the emotional significance of the moral judgment, which we refer to as emotional empiricism. (shrink)

Abstract:The problem this paper is concerned with is the politics of reforming embedded, parasitic, sometimes predatory, network-based, corruption subsystems. The politics of corruption subsystems is often embedded in social structures sustained by the collective action of interest groups who benefit from the corruption. Therefore, the long-term effectiveness of approaches that focus solely on isolated, individual acts of corruption are limited. The politics of long-term corruption reform can benefit from a combined action-learning and social movement–based collective approach.

This first volume of an ambitious three-volume work covers philosophic theory through McKeon's writings on first philosophy (metaphysics) and the methods and principles of the sciences.

There has been an exponential growth in research examining the neurological basis of human cognition and learning. Little is known, however, about the extent to which sports coaches are aware of these advances. Consequently, the aim of the present study was to examine the prevalence of pseudoscientific ideas among British and Irish sports coaches. In total, 545 coaches from the United Kingdom and Ireland completed a measure that included questions about how evidence-based theories of the brain might enhance coaching and (...) learning, how they were exposed to these different theories, and their awareness of neuromyths. Results revealed that the coaches believed that an enhanced understanding of the brain helped with their planning and delivery of sports sessions. Goal-setting was the most frequently used strategy. Interestingly, 41.6% of the coaches agreed with statements that promoted neuromyths. The most prevalent neuromyth was “individuals learn better when they receive information in their preferred learning style (e.g., auditory, visual, or kinesthetic)”, which 62% of coaches believed. It is apparent that a relatively large percentage of coaches base aspects of their coaching practice on neuromyths and other pseudoscientific ideas. Strategies for addressing this situation are briefly discussed and include changing the content of coach education programs. (shrink)

I address three distinct issues. What is a Catholic universit y? What is a Catholic theologian? What is the relationship of both to the Catholic Church? These three questions are addressed across several discussions from contemporary authors, with a brief historical survey of their recent development.

This commentary proceeds as follows. First, it is argued from both ethical and legal perspectives through an analysis of Court precedents that Etzioni’s has improperly developed a too narrow First Amendment interpretation and conclusion that Apple should comply with the FBI’s demand to provide the FBI with a key to open iPhones. That is, broad First Amendment considerations and not solely narrow First Amendment “compelled speech” or only Fourth Amendment privacy issues are offered and analyzed from both ethical and legal (...) perspectives. A key point here is that broad First Amendment considerations protect, with exceptions, political and ethical discretion space for “Press” organizations to exercise, or not, ethical responsibilities, including rights to publish or not publish information and opinions, rather than compliance with government orders to publish or not publish. Further, Court cases are discussed from both legal and ethical perspectives where the Courts have established that social media organizations such as Facebook and Twitter do and should have broad First Amendment protection of free expression and peaceful assembly as traditional media such as newspapers have. It is suggested that Apple can and should be considered a social media organization. In addition, special First Amendment protection and limitations concerning national security are analyzed. Second, it is suggested that Etzioni’s point that Apple protected its clients soley for “business profitability” reasons is also a too narrow interpretation since there are more complex, mixed, and combined ethical and political-economic reasons for protecting clients and First Amendment protections. Third, the philosopher Paul Ricoeur’s ethics process responsibility framework concerning relationships between ethics and law and the need for an ethics responsibility rather than a compliance approach, which is similar to Brandeis’ legal ethics approach, is compared with and offered as an alternative to Etzioni’s compliance based “Liberal communitarian” approach. It is suggested that the difference between the Rocoeur and Etzioni approaches is similar to the difference between compliance and ethics responsibility process programs in organizations. (shrink)

For as long as scholars have been presenting Asian thinkers to readers of European languages, efforts have been made to present the presumably less familiar Asian thinkers as having points of commonality with the presumably more familiar European thinkers. In presenting classical Indian Buddhist philosophers to his readers in the 1920s and 1930s, for example, Stcherbatsky portrayed them as anticipating important features of European philosophers. In his study of Madhyamaka, Nāgārjuna and Candrakīrti are depicted as adumbrating the philosophy of Kant (...) and Hegel. In the works of other scholars, the presentation of early Buddhism as an anticipation of aspects of Hume became commonplace. A number of scholars have... (shrink)

There are several different types of capitalist political-economies and business organizations. Consequently, the implications for business citizenship behaviors are also quite different. In the older “large family owned business” and “managerial capitalism” forms there are important structural opportunities for a social contract and balancing of the needs of various stakeholder groups. In the “investor capitalist” form which emerged in the 1980s and has come to dominate the U.S. political-economic system, there is a dominant priority toward optimization of the shareholder wealth (...) criterion which makes it very difficult for such business organizations to engage in authentic citizenship behaviors. (shrink)

If, as Buddhism claims, the potential for awakening exists in all human beings, we should be able to map the phenomenon with the same science we apply to other forms of consciousness. A student of cognitive social science and a Zen practitioner for more than forty years, Richard P. Boyle brings his sophisticated perspective to bear on the development of a theoretical model for both ordinary and awakened consciousness. Boyle conducts probing interviews with eleven prominent Western Buddhist teachers and (...) one scientist who have experienced awakening. From the paths they traveled to enlightenment and their descriptions of the experience, he derives three fundamental properties of awakened consciousness. He then constructs an overarching model that explains how Buddhist practices help free the mind from attachments to reality and the self and make possible the three properties of awakening. Specifically, these teachers describe how they worked to control attention and quiet the mind, detach from ideas and habits, and open themselves to compassion. Boyle's account incorporates current theories of consciousness, sociological insights, and research in neuroscience to advance the study of awakened consciousness and help an even greater number of people to realize it. (shrink)

On the basis of the Weber, Jaspers, and Arendt style ‘ideal types’ of the manager as Eichmann, Richard III, and Faust it is explained how under strong organizational pressures to obey orders and further organizational ends, different types of managers cooperate with organization behavior that harms people. On the basis of Arendt's and Tillich's action philosophies, the manager as Institution Citizen with the courage to be both as oneself and as a part is presented as alternative, contrast, and resistance (...) model to the other ‘ideal types’, particularly to the Eichmann ‘ideal type’. (shrink)

We introduce stellar photometry, its purpose and relationship to other astronomical quantities, presenting it within the context of astronomical research at the Vatican Observatory. We demonstrate the usefulness of the Vilnius Photometric System previously shown at Vilnius Astronomical Obs., Edinburgh Royal Obs., and Università di Roma “La Sapienza”, and then adopted by the Vatican Observatory for use with its Vatican Advanced Technology Telescope on Mount Graham, AZ, USA. The development of astronomical observations has led from photographic plates, through photoelectric detectors (...) to the use of sensitive CCD cameras. Expanding the photoelectric databank of “Vilnius Stars”, we describe the development of new techniques of data-acquisition, calibration to photometric standards, stellar classification and interstellar-matter characterization. Looking ahead, we briefly describe the extensive data set, and our plans for further detailed analyses. (shrink)

Action research is combined research and practical action where the researcher joins with and acts with practitioners to help improve practice and theory building. Action research can be a form of Aristotelian critical, ethical praxis that developmentally changes the action researcher and the external world. Bernstein’s and Eikeland’s interpretations of Aristotelian ethics praxis are considered. The Argyris et al. “action-science” and the van de Ven “engaged scholarship” forms of action research with their differently nuanced interpretations of Aristotelian philosophy as foundations (...) for action research are considered and compared as examples of action research as an ethics praxis method with respect to a key similarity with respect to joining of critical ethics and actionable knowledge; another key similarity with respect to action research practice that can developmentally change the action researcher and the external world; and a key difference with respect to academic literature versus practitioner-based theory building is also considered. Examples in the cases of the political economist and action researcher, Hirschmann’s “Exit,Voice, Loyalty” approach and Greenleaf’s “Servant Leadership” approach to action research as forms of Aristotelian critical, ethical praxis are analyzed. (shrink)

Abstract:There can be ethical understanding of organizational policy issues and that is important. However, there can be policy understanding about what the organization should do without understanding of individual level responsibility. There can be cognitive understanding of both policy and individual level ethics responsibilities and that is important. However, there can be cognitive understanding without affective, emotive concern. Intellectual understanding without affective concern can lead to understanding without motivation. There can be cognitive understanding and affective concern and that is important, (...) but not enough. There can be cognitive understanding and affective concern without effective political method. An action-learning approach to organizational ethics can join cognitive understanding of policy and individual level issues with both affective concern and effective political method. Joining of cognitive understanding, affective concern, and effective political method can stimulate and enable ethical character. (shrink)

The doctrine that there is no permanent creator who superintends creation and takes care of his creatures accords quite well with each of the principles known as the four noble truths of Buddhism. The first truth, that distress is universal, is traditionally expounded in terms of the impermanence of all features of experience and in terms of the absence of genuine unity or personal identity in the multitude of physical and mental factors that constitute what we experience as a single (...) person. As we saw above, the principal Buddhist arguments against the existence of God focus on the impossibility of permanence and unity in the causal structure of the universe. The second noble truth, that distress is the outcome of one's own unrealistic aspirations, is traditionally seen as ruling out the erroneous view that distress is something inflicted upon creatures by a cosmic superintendent or by other circumstances completely beyond their control. The third noble truth, that distress can be eliminated by divesting oneself of all unrealistic aspirations, rules out the view that sentient beings, as powerless victims of a divine will, have no alternative to a life of constant frustration. And the fourth noble truth, that the best means of removing unrealistic desires is to follow a methodical course of self-discipline, counters the view that the road to happiness lies in obedience to divine will or in trying to manipulate the sentiments of a cosmic intelligence through prayer or ritual. (shrink)

Philosophical discussions of health and disease have traditionally been dominated by a debate between normativists, who hold that health is an inescapably value-laded concept and naturalists, such as Christopher Boorse, who believe that it is possible to derive a purely descriptive or theoretical definition of health based upon biological function. In this paper I defend a distinctive view which traces its origins in Aristotle's naturalistic ethics. An Arisotelian would agree with Boorse that health and disease are ubiquitous features of the (...) natural world and thus not mere projections of human interests and values. She would differ from him in rejecting the idea that value is a non-natural quality. I conclude my discussion with some comments of the normative character of living systems. (shrink)

Introduces the spiritual ideas of three major American philosophers.

Internal due process systems are the formal mechanisms thatmany organizations use to address and resolve ethics conflicts.Problematical due process systems such asinvestigation-punishment and grievance-arbitration systemsnarrowly constrain the political and moral space needed formeaningful ethics voice, praxis, and community. The relativelyuncommon employee board and mediator-counselor types of systemscan help solve such problems. The employee board andmediator-counselor systems permit questioning not only of guiltwith respect to policy violations but also the appropriateness ofthe policies as well as potential biases in an organization'sembedded tradition-system (...) that may be contributing to unethicalbehavior. Theoretical implications for organization ethics,praxis, community, and integrative social contracts theories areexplored. Several case examples are discussed. (shrink)

It has been suggested that the enterprise of developing mechanistic theories of the human cognitive architecture is flawed because the theories produced are not directly falsifiable. Newell attempted to sidestep this criticism by arguing for a Lakatosian model of scientific progress in which cognitive architectures should be understood as theories that develop over time. However, Newell's own candidate cognitive architecture adhered only loosely to Lakatosian principles. This paper reconsiders the role of falsification and the potential utility of Lakatosian principles in (...) the development of cognitive architectures. It is argued that a lack of direct falsifiability need not undermine the scientific development of a cognitive architecture if broadly Lakatosian principles are adopted. Moreover, it is demonstrated that the Lakatosian concepts of positive and negative heuristics for theory development and of general heuristic power offer methods for guiding the development of an architecture and for evaluating the contribution and potential of an architecture's research program. (shrink)

Together, the writings in this book show how McKeon reinvented the ancient arts of rhetoric, grammar, logic, and dialectic for the new circumstances of a global culture.

The institutions of science arecomposed of communities with conflicting andoverlapping interests. In the United States,the internal governance of science resemblesthe structure of republican government,particularly in its fragmentation,representation, and extension. This articlecalls upon Michael Polanyi's metaphor of a`Republic of Science' in the context ofAmerican history and political theory, toexamine the ways in which these interests arerepresented. Using the metaphor obliges us toask about rules of citizenship in the`Republic', and to determine whether those whopay for science should also be represented inits institutions.

We consider approaches to explanation within the cognitive sciences that begin with Marr's computational level or Marr's implementational level and argue that each is subject to fundamental limitations which impair their ability to provide adequate explanations of cognitive phenomena. For this reason, it is argued, explanation cannot proceed at either level without tight coupling to the algorithmic and representation level. Even at this level, however, we argue that additional constraints relating to the decomposition of the cognitive system into a set (...) of interacting subfunctions are required. Integrated cognitive architectures that permit abstract specification of the functions of components and that make contact with the neural level provide a powerful bridge for linking the algorithmic and representational level to both the computational level and the implementational level. (shrink)

Dialogic leadership as ethics method respects, values, and works toward organizational objectives. However, in those situations where there may be conflicts and/or contradictions between what is ethical and what is in the material interest of individuals and/or the organization, the dialogic leader initiates discussion with others (peers, subordinates, superiors) about what is ethical with at least something of a prior ethics truth intention and not singularly a value neutral, constrained optimization of organizational objectives. Cases are considered where dialogic leadership: (1) (...) helped build ethical organizational culture; (2) was effective; and, (3) as a by-product, produced integrative win-win results. Philosophical foundations for the method as well as differences between dialogic leadership and Theory X forcing leadership, Theory Y win-win integrative leadership, industrial democracy, participative management, action inquiry, and double-loop learning action science are explored. Limitations of the method are also explored. (shrink)

Organization ethics praxis is theory and method of appropriate action for addressing ethics issues and developing ethical organizations. The perspective of praxis (theory and method of action) is important and different from the perspectives of theoria (theory of understanding), epistemology (ways of knowing), and ontology (ways of being/existing). Praxis is the least developed area within the field of organization ethics. Differences between theoria and praxis are considered within the context of Kohlberg—Gilligan developmental ethics where part of the controversy may be (...) unnecessary due to Kohlberg’s concentrating on epistemology and theoria, but not praxis; and, Gilligan’s considering aspects of praxis with epistemology and theoria. Differences between epistemology and praxis perspectives are considered in the contexts of two cases: Socratic “double-loop” action-learning conversations the night before the Challenger explosion; and, “triple-loop״ action-learning in a cross-cultural Boston—Indonesia child worker safety, acid-washed jeans case. (shrink)

In this ground breaking and controversial work Richard Bentall shatters the myths that surround madness. He shows there is no reassuring dividing line between mental health and mental illness.

It is well established within the ethics and institutional theory literatures that institutions can have conflicting logics with ethical dimensions and that there are solutions to the conflicts. Within institutional, ethics, and change leadership theory, quantitative, mixture solutions such as distributive solutions have been frequently considered. The ethics, institutional, and change leadership theory literatures have recognized that there are qualitative transformational solutions that are different than quantitative mixture solutions. However and for the most part, with the notable exception of the (...) Thornton et al. :801–843, 2012) typology of solutions, the institutional, change leadership, and ethics literatures have not considered typologies of transformational solutions. And more specifically with respect to this article, the institutional, change leadership, and ethics literatures have not considered different types of transformational solutions to institutional logic conflicts with ethical dimensions. This article: develops a typology of transformational solutions; applies the typology with historical examples of conflicting institutional ethics logics within factory, cultural, and institutional social change leadership cases; and, considers practical and theoretical implications for institutional ethics change leadership for achieving and/or resisting different types of transformational solutions. (shrink)